A thirty-child chart review found little reported improvement with clonazepam. Its retrospective multiple-treatment sequence could not establish a definitive comparative treatment ranking.
The clinical cohort
Children at a tertiary center often had structural injury and substantial delay between symptom onset and treatment. Several drugs and dietary therapy were used, with clonazepam recorded across the cohort.
Response categories included spasm cessation, partial improvement, and no improvement. The report described limited clonazepam response and more favorable results with several other approaches.
Sequence and selection matter
Treatment groups overlapped and were not randomized. A drug tried later in more resistant disease may appear less effective for reasons beyond its intrinsic effect. Different response denominators and time windows also matter.
The small tertiary sample cannot define the response rate in every infantile-spasm population. The study supports recording etiology, delay, EEG evolution, prior therapies, and exact response criteria. It does not establish that clonazepam never helps, that a different treatment would have prevented a particular injury, or that prescription frequency measures effectiveness.
Source paper
Original analysis of the supplied journal article, identified as PMC8132827.
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