An observational dental series linked additional intravenous diazepam with lower first-day acetaminophen use, but treatment selection limits the inference.
What happened in the series
All 50 patients with a previous myocardial infarction received oral chlordemethyldiazepam before extraction. Twenty-three who did not feel fully relaxed received additional intravenous diazepam. First-day acetaminophen use was reported in 60.87% of that subgroup compared with 88.89% of those without the additional intravenous drug.
Anxiety treatment is not a randomized analgesia test
The intravenous intervention was based on remaining anxiety, not random allocation. Differences in patients, procedures, expectations, or reporting could contribute to subsequent analgesic use. All patients already had benzodiazepine exposure, so the comparison was not benzodiazepine versus no benzodiazepine. The modest sample and selected cardiac-history population also constrain generalization. The study suggests an association worth examining, but it does not show that diazepam directly relieved extraction pain or establish safety for every patient with cardiovascular disease.
Source paper
Original analysis of the supplied journal article, identified as PMC6988723.
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