Diazepam Resistance in END-IT Did Not Make the Score a Reliable Predictor in This Small Cohort

A retrospective status-epilepticus study found the composite END-IT score performed poorly for functional outcome prediction.

A component of a larger score

END-IT combines encephalitis, nonconvulsive status, diazepam resistance, imaging abnormalities and intubation. The investigators evaluated this and two other scores in 55 patients. STESS was more sensitive and EMSE more specific in their analysis, while END-IT predicted function poorly.

A component is not an independent prognosis

The result does not show that diazepam resistance alone determines recovery or that initial response guarantees a favorable outcome. The small, single-center retrospective cohort also limits precision and external validity. Composite performance depends on how features are defined and combined, and it can change across populations. In an individual case, retain seizure cause, duration, electrical findings, treatment sequence and follow-up rather than using one drug-response observation as a definitive forecast of disability.

Source paper

Original analysis of the supplied journal article, identified as PMC6678186.

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