All Articles
Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
Repeated Allergy Testing Case Did Not Identify Midazolam as the Culprit
A perioperative allergy case illustrates why the presence of midazolam in an anesthetic history does not establish that it caused a reaction.
Dementia Visit Study Found Similar Combined Benzodiazepine and Z-Drug Reporting
A US ambulatory-care analysis found more overall cognitive-risk prescribing in dementia visits, but the combined benzodiazepine/Z-drug category looked similar across groups.
Thousands of EEG Epochs Still Came From Seventeen Status-Epilepticus Patients
A refractory-seizure study shows why a large number of repeated measurements is not the same as a large clinical sample.
Hysteroscopy Sedation Trial Used Proxies Under a Maternal–Fetal Safety Label
A remifentanil-versus-midazolam trial reported clinical recovery differences, but its reproductive-safety interpretation requires a narrower reading.
Ethiopian Cohort’s Hospitalization Estimate Applied to All Flagged Medications
A multicenter study associated potentially inappropriate medication exposure with hospitalization, but its overall estimate was not a benzodiazepine-specific effect.
Ethics Article Treats Emotional-Distress Prescribing as a Communication Problem Too
A bioethics paper examines why benzodiazepine prescribing for emotional distress can involve more than symptom suppression.
Canadian Death Review Distinguished Detected Drugs From Drugs Judged Contributory
A national review of accidental toxicity deaths shows why a toxicology finding and a cause-of-death judgment should be recorded separately.
End-of-Life Anxiety Review Included Only Two Benzodiazepine–Opioid Studies
A systematic review found a limited evidence base for pharmacological anxiety treatment near the end of life.
Cancer Delirium Cohort Examined Outcomes Only After Delirium Developed
A retrospective oncology study associated prior benzodiazepine exposure with some poorer outcomes among patients already selected for delirium.
Nurse-Driven Alcohol-Withdrawal Project Measured Adoption Before Clinical Effectiveness
A hospital implementation study found increasing use of a symptom-triggered withdrawal protocol while identifying remaining fidelity gaps.
Delirious-Mania Series Used Several Treatments Alongside Lorazepam
A four-patient series reports improvement in a complex syndrome but cannot isolate lorazepam’s contribution.
Aphasic Seizure Cases Show Why Language Dysfunction Is Not a Sedation Measure
Two case reports describe aphasic status epilepticus, a seizure presentation that can resemble other causes of acute language disturbance.
Bayesian Clobazam Adherence Modeling Depends on Prior Assumptions
A simulation-based framework illustrates why a drug concentration cannot reveal adherence without assumptions about the patient and dosing history.
Hysteroscopy Meta-Analysis Claimed a Nausea Benefit That Its Interval Did Not Establish
A source appraisal finds that the nausea-and-vomiting conclusion in a remimazolam meta-analysis is stronger than the reported estimate supports.
Sleep-Related Scratching Series Reported Clonazepam Responses Without Proving Mechanism
A small sleep-medicine series describes amnestic nocturnal scratching and responses to several treatments, including clonazepam in some cases.
Cancer Prescribing Review Found Both Inappropriate Use and Unmet Mental-Health Needs
A review of psychoactive medication in cancer care describes a balance between avoidable exposure and undertreated psychological distress.
Sparse-Sampling Bioequivalence Models Reconstructed Alprazolam and Clonazepam Curves
A modeling study tested whether limited blood samples could reproduce formulation comparisons from existing bioequivalence datasets.
Microdose Study Found Higher Midazolam Exposure in Older Participants
A phenotyping-cocktail study found age-related differences in midazolam pharmacokinetics, including in older adults with kidney disease.
Zolpidem Review Found a Balance Signal Despite No Clear Cognitive-Test Difference
A review of placebo-controlled trials in older adults separated acute balance effects from the cognitive outcomes measured.
Temazepam EEG Study Used a Fixed Placebo-Then-Drug Sequence
A small sleep study found lower EEG complexity on a temazepam night, but the design limits claims about individual drug effects.
Repeat Dabrafenib Reduced Midazolam Exposure in a Clinical Interaction Study
A cancer-drug interaction study found that repeat dabrafenib substantially reduced exposure to oral midazolam used as a CYP3A probe.
Psychiatric Driving Review Found That Treatment Stage Matters
A systematic review found that driving-related performance under psychiatric medication depended on the drug, illness, and duration of treatment.
Dementia Prescribing Study Followed Medication Patterns Around AChEI Initiation
A Norwegian registry study found sex-related prescribing patterns before and after initiation of an acetylcholinesterase inhibitor.
Tunisian Urine Survey Described a Police-Selected Sample and a Limited Test Panel
A large forensic urine survey describes detected drugs among suspected users rather than prevalence in the general population.
GABAA Receptor Experiments Identified Subunit-Dependent Spontaneous Gating
A receptor study shows why GABAA signaling cannot be reduced to a single uniform channel response.
Mouse Zona-Incerta Experiments Localized Several Anxiety-Related Responses
A neuroscience study used local diazepam administration and cell-specific experiments to investigate anxiety circuits in mice.
Bronchoscopy Spray Study Changed Local Anesthesia While Retaining Midazolam
A small bronchoscopy comparison examined tolerance of a different throat-anesthesia approach, rather than the effect of removing benzodiazepine sedation.
Norwegian Treatment Cohort Used a Composite Substance-Use Severity Index
A prospective substance-treatment cohort found no clear overall reduction on its composite index, which included benzodiazepines and several other substances.
Midazolam-Coated Nanoparticles Were Tested as a Brain-Delivery Platform
A preclinical formulation study used midazolam as part of a nanoparticle design, not simply as an administered sedative.
Chronic-Pain Survey Found a Gap Between Overdose Risk Factors and Perceived Risk
A survey of opioid-treated patients found low perceived overdose risk despite frequent concurrent risk factors, including benzodiazepine prescriptions.