All Articles
Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
Dutch Lockdown Study Counted New Hypnotic Dispensing, Not Untreated Insomnia
First-time hypnotic dispensing fell during the first Dutch COVID-19 lockdown, but the data did not establish that sleep problems became less common.
Hysterectomy Trial Found Worse First-Night Sleep Measures With Remimazolam
One randomized trial reported poorer early sleep measures after remimazolam anesthesia than after propofol, with important differences between total scores and diagnostic categories.
Psychiatric Alcohol-Treatment Survey Described Prescribing Rather Than Withdrawal Efficacy
A large historical inpatient dataset documented changing drug use for alcohol-related diagnoses, without comparing randomized withdrawal regimens.
Hip-Fracture Registry Analysis Used Recent Dispensing Rather Than Drug Levels
A Dutch case-control study associated benzodiazepine–opioid dispensing with hip fracture treated by arthroplasty, without proving medication impairment at the fall.
Grapefruit Probe Study Contrasted Human Midazolam Exposure With a Mouse-Based Berry Hypothesis
Repeated grapefruit intake increased midazolam exposure in healthy volunteers, while lingonberry powder did not reproduce the enzyme induction previously suggested in mice.
Addiction-Service Staff Confidence Did Not Validate Intoxication Detection
A staff survey identified practical barriers to assessing intoxication, without testing whether confident clinicians classified patients accurately.
Sleepwalking Case Reported Symptom Relief Without Showing That Clonazepam Treated OSA
A case involving obstructive sleep apnea illustrates why improvement in one sleep complaint does not establish resolution of another.
Methadone Cohort Found More Benzodiazepine Prescribing in Patients With PTSD
A cohort of people receiving opioid-use-disorder treatment found clinically different groups that require caution in medication-outcome comparisons.
Feline Epilepsy Surgery Case Cannot Isolate Diazepam Tolerance
A veterinary case describes worsening structural epilepsy despite a multi-drug regimen, not a controlled test of one benzodiazepine.
Tetanus Review Separates Spasm Suppression From Removal of the Disease Process
A critical-care review places benzodiazepines within multi-component management of severe tetanus rather than presenting them as a complete antidote.
Hemodialysis Insomnia Review Found Different Answers for Mean Scores and Response Thresholds
A review comparing auricular acupressure with estazolam illustrates why outcome definitions can change the apparent result.
HIV Claims Cohort Linked Benzodiazepine Use With Later Chronic Opioid Treatment
A historical Medicaid study identified benzodiazepine use as a predictor of chronic opioid treatment, not as proof of opioid-related injury.
Burning-Mouth Prediction Study Did Not Show That Two-Thirds of Patients Responded
A machine-learning paper’s prediction accuracy should not be mistaken for clonazepam’s treatment success rate.
Chinese Cancer Claims Study Counted Midazolam Without Establishing Its Indication
A large utilization study found frequent midazolam records, but a claims category does not prove treatment of psychiatric illness.
Refractory-Seizure Review Requires More Than the Label “Benzodiazepine Failure”
A seizure-treatment review emphasizes the adequacy and sequence of earlier treatment when classifying refractory status epilepticus.
Dystonia Review Treats Benzodiazepines as One Symptomatic Option Among Several
A movement-disorder review does not support treating every dystonia or tic syndrome with the same medication strategy.
Insomnia Interviews Found That Sleep-Hygiene Advice Was Not the Same as CBT-I Access
A qualitative primary-care study identified a gap between willingness to manage insomnia and access to structured behavioral treatment.
Early Korean COVID Cohort Did Not Find a Significant Benzodiazepine Mortality Association
A population-based historical analysis found different results across medication groups, including a nonsignificant benzodiazepine comparison.
High-Dose Sedative Study Used an ADHD Screen Rather Than a Standalone Diagnosis
A treatment-seeking sample found an association between positive ADHD screening, executive function, and reported quality of life.
Norwegian Peer-Group Project Increased Recorded Reviews and Reduced Dispensed Benzodiazepine Doses
A local quality-improvement project linked collaborative learning with changes in prescribing indicators.
Older-Adult Psychotropic Review Found Agreement on Long-Term Use Alongside Barriers to Change
A stakeholder review suggests that persistent prescribing can reflect shared expectations and system limitations rather than one clinician’s knowledge alone.
Dravet Review Places Clobazam Within a Multi-Drug Interaction Problem
A practical review explains why clobazam treatment in Dravet syndrome must be interpreted within the full antiseizure regimen.
Military Naloxone Study Compared Observed Growth With a Forecasted Trend
A policy evaluation found increasing naloxone prescribing without demonstrating a significant increase beyond the trajectory predicted from earlier data.
Abdominal Dyskinesia Cases Combined Clonazepam With Vitamin B12 Treatment
A three-patient report describes improvement in abnormal abdominal movements without establishing which component of treatment was responsible.
Neck-Muscle Injury Series Proposed a Mechanism After Mixed Opioid and Sedative Use
An eight-patient series describes severe weakness and neck-muscle injury after polysubstance exposure, while leaving the proposed causal pathway uncertain.
Insomnia Decision Aid Was Tested for Acceptability Rather Than Successful Withdrawal
A decision-aid development study evaluates whether information and choices are usable, not whether every user can discontinue hypnotics.
Historical REM-Behavior Review Distinguished Symptom Treatment From Disease Prevention
A 2021 review describes clonazepam as a commonly used symptomatic treatment while emphasizing limits in controlled evidence.
Pediatric Inflammation Review Found Sparse and Age-Dependent Midazolam Clearance Evidence
A systematic review suggests that inflammation can alter drug metabolism in children, with effects differing by pathway and age.
Rat PET Study Found That the Anesthetic Regimen Changed the Apparent Brain Signal
A preclinical imaging study shows that sedation can affect the measurement used to study brain metabolism.
Status-Epilepticus Trial Reanalysis Found Functional-Seizure Misdiagnosis and Treatment Harm
A reanalysis of emergency seizure trials found that some patients treated for status epilepticus ultimately had prolonged functional seizures.