All Articles
Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
Resistant-Panic Case Added Atomoxetine to a Regimen That Had Included Clonazepam
A single case reported improvement after several unsuccessful augmentation approaches. It did not establish atomoxetine as a proven alternative to benzodiazepines for panic disorder.
Psychotropic Sexual-Function Study Could Not Isolate a Benzodiazepine Effect From Combination Treatment
A cross-sectional outpatient study found sexual dysfunction more often with antidepressant–benzodiazepine combinations. Small drug-specific groups prevented firm attribution to individual medicines.
Sexsomnia Case Reported Clonazepam Benefit for Sleepwalking but Not Sleep Masturbation
A video-polysomnography case documented different responses in two sleep behaviors. Improvement in sleepwalking did not mean the entire parasomnia presentation resolved.
Volatile-Sedation Pilot Protocol Compared Delivery Feasibility With Midazolam or Propofol Care
A planned ICU pilot emphasized environmental exposure and protocol adherence. It did not provide completed evidence that inhaled sedation shortened ventilation compared with benzodiazepines.
Buccal-Midazolam Training Project’s Online Test Assessed Knowledge Rather Than Bedside Performance
A quality-improvement project found that about one in five carers failed an online rescue-medication test. The test did not directly observe administration during seizures.
Finnish Long-Acting Buprenorphine Fatality Series Found Unprescribed Benzodiazepines Among Co-Exposures
A small fatality audit identified frequent additional drug exposure during long-acting buprenorphine treatment. Its death-only sample could not compare treatment mortality rates.
Spanish Poisoning-Admission Audit Counted Episodes Separately From Individual Patients
A seven-year hospital study found benzodiazepines commonly coded in poisoning admissions. Recurrent admissions mean episode counts cannot be treated as the number of different people poisoned.
Paliperidone-Missed-Dose Case Described Prolonged Benzodiazepine Treatment for Malignant Catatonia
A report associated catatonia with a missed long-acting antipsychotic dose and described improvement during high-dose benzodiazepine care. It did not prove withdrawal as the sole cause.
Four-City Brazilian Autopsy Study Could Not Determine Whether Benzodiazepine Use Was Prescribed
A postmortem study found benzodiazepines in twenty percent of self-harm cases. Missing medical histories prevented distinguishing supervised treatment from other use.
Four-Week Thai Insomnia Trial’s Nonsignificant Group Difference Was Not Proof of Equivalence to Lorazepam
A sixty-person trial compared a Thai herbal preparation, cannabis oil, and lorazepam. All groups improved, but the small open-label study did not establish formal therapeutic equivalence.
Small Ventilation Trial Reduced Midazolam Use With Structured Sedation Assessment
A thirty-patient study found lower midazolam dosing after protocol-based assessment. It did not establish an equally large effect on every ventilation or safety outcome.
Kano Eclampsia Program Reported Lower Fatality After Magnesium Replaced Diazepam-Based Care
A retrospective implementation study reported a large reduction in eclampsia case fatality after introducing magnesium sulfate. The program comparison did not randomize individual patients.
Anti-NMDA Encephalitis Case Improved With ECT After Benzodiazepine and Immune Therapy
A pediatric case describes persistent malignant catatonia despite several treatments, followed by improvement after ECT. The sequence cannot isolate one intervention from the evolving autoimmune illness.
First-Episode Depression Cohort Treated Sedative Load as a Severity Marker
A small longitudinal-record cohort associated higher lorazepam-equivalent sedative load with more intensive depression care. Higher load did not establish stronger treatment efficacy or medication-caused illness.
Depression Case Illustrates How Recognizing Catatonic Features Changed Lorazepam Treatment
A report of a woman with depression describes improvement after clinicians recognized catatonic signs and added lorazepam. It provides a diagnostic example rather than a treatment-success estimate.
Diazepam Mouse Study Distinguished Reduced Anxiety-Like Behavior From Behavioral Inactivity
A study in two mouse strains found different responses to diazepam. Less movement in a test did not necessarily mean the same anxiolytic effect in both strains.
Structural GABA-A Study Mapped Diazepam and Alprazolam Binding Without Measuring Human Impairment
A structural study visualized selected ligands bound to a defined human receptor assembly. It explains molecular interaction, not the clinical effect of a given blood concentration.
Pediatric Bronchoscopy Review Compared Score-Guided Titration With Experience-Based Midazolam Dosing
A retrospective study associated a structured sedation scale with lower doses and fewer recorded adverse reactions. The intervention changed the dosing process, not the drug itself.
Serotonin-Syndrome Hypertension Review Relied on Case Reports Rather Than Comparative Trials
A case-based review discussed benzodiazepines and other measures for severe hypertension during serotonin syndrome. The evidence did not establish comparative treatment success rates.
Older-Adult Function Study Found Benzodiazepine Associations Differed by Outcome and Sex Stratum
A longitudinal community study associated psychoactive medication with later disability. The benzodiazepine finding concerned a specific functional domain and subgroup, rather than every older adult.
Alprazolam Islet Study Combined Human Cells With a Mouse Transplant Model
A preclinical study found increased survival and replication of transplanted human islet cells with alprazolam. Human tissue in an animal model is not a clinical diabetes-treatment trial.
Prostate-Biopsy Sedation Paper Specified a Severe-Apnea Endpoint in a Trial Protocol
A supplied paper outlines a remimazolam-versus-propofol comparison in older men. It sets out a planned respiratory endpoint rather than reporting the trial’s completed treatment effect.
Gastric Dissection Trial Found Less Propofol but Longer Recovery With Added Midazolam
A randomized deep-sedation study reported a tradeoff between propofol requirement and recovery time. The combination did not improve every outcome in the same direction.
Regional Hand-Anesthesia Trial Tested Midazolam Inside a Tourniquet-Isolated Lidocaine Regimen
A sixty-patient trial reported improved block and pain measures after adding midazolam to intravenous regional anesthesia. The specialized delivery context limits generalization to systemic sedation.
Preschool Dental Trial’s Higher Combination Success Counts Had Wide Intervals and a Nonsignificant Comparison
A randomized dental study found numerical advantages for ketamine–midazolam combinations, but did not establish superiority on its predefined behavioral success comparison.
Ventilated-Child Trial Found Less Rated Undersedation With Fentanyl Added to Midazolam
A forty-four-patient randomized trial found improved sedation-target measures with the combination. Its observation period did not include later withdrawal or dependence outcomes.
SOMNUS Protocol Planned to Test Prescribing Nudges and Track Benzodiazepine Orders as a Secondary Outcome
A cluster-randomized trial protocol proposes changing electronic prescribing defaults and prompts. It describes planned measurements, not demonstrated reductions in sedative use.
Hospital Booklet Pilot Did Not Show More Benzodiazepine-Review Conversations Than Usual Care
A small randomized feasibility study found similar discussion rates with and without an educational booklet. Medication cessation in the overall sample did not demonstrate a booklet effect.
Hypnotic Hair Review Explained Why Dyeing and Incorporation Pathways Complicate a Calendar of Use
A forensic review describes sensitive hair testing for hypnotics, including single-exposure investigations. Timing and amount cannot be reconstructed from segment position alone.
Compensated-Cirrhosis Endoscopy Study Found Longer Recovery With Midazolam Than With Propofol
A ninety-patient comparison found substantial recovery-time differences between selected sedation regimens. The results apply to compensated cirrhosis and do not define recovery for every patient with liver disease.