All Articles
Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
GHB-Withdrawal Baclofen Paper Was a Feasibility Protocol Alongside Usual Benzodiazepines
A study-design paper proposed testing baclofen as an adjunct during GHB or GBL withdrawal. It reported planned comparisons rather than completed proof of efficacy.
Four Pediatric Catatonia Cases After Illness Supported Diagnostic Consideration Without Validating a Perfect Test
A small series described lorazepam responses in children with motor and verbal unresponsiveness after illness. Its strong wording about the challenge test exceeded what four cases could establish.
79-Child MRI Trial Reported Slower Remimazolam Induction but Faster Recovery and Fewer Repeated Doses
A small randomized MRI study found different advantages across onset, recovery, and supplementation. Its abstract and later limitation wording did not agree on which group required more supplementation.
Gynecologic Induction Study Estimated Lower BIS-Target Doses in Older Patients Receiving Sufentanil
A dose-ranging study found age-related differences in remimazolam amounts required to reach a BIS endpoint. The result depended on an accompanying opioid and did not measure plasma exposure.
Randomized Tonsil-Surgery Study Reported Less Emergence Agitation With Remimazolam–Remifentanil
A 120-child trial compared two opioid-containing anesthetic regimens. Its emergence findings concern those complete regimens in one surgical setting.
Remimazolam Anaphylaxis Report Combined Chronology, Tryptase and Later Skin Testing
A severe perioperative case supplied several lines of evidence for hypersensitivity after remimazolam. The report could not fully separate the molecular trigger or the contribution of spinal blockade.
Iceland Study Defined Persistent New Benzodiazepine Use Through a Second Post-Discharge Prescription
A retrospective hospital study found new benzodiazepine dispensing after discharge and subsequent repeat dispensing. Its operational definition did not establish daily consumption or a substance use disorder.
Pediatric Emergence-Delirium Study Estimated a Regimen-Specific ED90 Rather Than a Safety Ceiling
A sequential dose-finding study estimated a remimazolam bolus associated with 90% prevention of rated emergence delirium. That model estimate is not a universal pediatric dose recommendation.
Propofol–Midazolam Safety-Signal Study Measured Disproportionate Reporting Rather Than Event Incidence
A FAERS analysis found safety signals involving propofol and midazolam. Its reporting-odds ratios describe patterns among submitted reports, not the probability that a treated patient will experience an event.
Antiseizure-Adjunct Review Found Withdrawal Relief and Lasting Benzodiazepine Cessation Were Different Outcomes
A review of adjunctive antiseizure medicines found small and inconsistent studies. Short-term symptom improvement did not reliably establish durable benzodiazepine discontinuation.
Neonatal Rat Midazolam Study Found Developmental Effects That Varied by Age and Endpoint
A preclinical study followed rats after chronic neonatal midazolam exposure. Changes in growth, brain measures, and behavior were not uniform across developmental stages.
Spinal-Anesthesia Trial Compared Loading Strategies as Well as Adding Midazolam
A ninety-patient study compared midazolam loading followed by dexmedetomidine with dexmedetomidine loading and infusion. It changed the loading strategy, so it was not simply a test of adding one drug.
Pediatric Marrow-Procedure Trial Favored Oral Midazolam–Ketamine but Had Reporting Limits
A small pediatric trial reported better sedation and pain-related ratings with the combination than with midazolam alone. Numerical and methodological limitations constrain its broader claims.
Ninety-Child Premedication Trial Found Deeper Sedation With Combined Midazolam and Ketamine
A randomized preoperative study found better immediate behavior and deeper sedation with its combination regimen. The postoperative behavioral comparison did not show the same advantage.
Thirteen-Child Study Compared Nasal Midazolam Plasma Levels With Syringe and Atomizer Delivery
An exploratory emergency study found no significant difference in early plasma levels between two delivery methods. The small comparison did not establish clinical equivalence.
Seventeen-Trial Review Associated Remimazolam With Lower Postoperative Delirium Odds Than Propofol
A meta-analysis of 17 randomized trials reported lower pooled odds of postoperative delirium with remimazolam. Variation in procedures, drug regimens, and delirium assessment constrains a universal safety ranking.
Infant CT Trial Found Higher Initial Midazolam Success but Frequent Need for Rescue Sedation
A randomized infant CT-sedation study found more initial success with its higher-dose midazolam regimen. Even so, many children required additional treatment.
Zopiclone Case Described Agitation Resolving After Flumazenil in an Older ICU Patient
A case report described confusion and agitation after zopiclone, followed by rapid improvement after flumazenil. The authors treated the drug relationship as suspected, with competing medical explanations.
Taiwan Case-Control Study Associated Benzodiazepine Prescriptions With Later Epilepsy Diagnosis
A claims-based study found an association between benzodiazepine exposure and epilepsy diagnosis. The authors also recognized reverse causality and missing confounders, which limit individual causal conclusions.
Fruit-Drink HPLC Study Distinguished Benzodiazepine Detection Limits From Its Calibration Range
A laboratory study developed HPLC-UV testing for six benzodiazepines in spiked fruit-based drinks. It demonstrates an analytical application, rather than the frequency or circumstances of drink adulteration.
Catatonia Improved With Lorazepam Before a Reported Cardioembolic Stroke
A 2026 case described improvement in catatonia after lorazepam despite persistent cardiac disease and a later stroke. Improvement in one syndrome did not establish resolution of the patient’s other risks.
German Adult Status-Epilepticus Guideline Separates Initial Benzodiazepines From Later Treatment Stages
The supplied 2021 German guideline places benzodiazepines within a staged approach to adult status epilepticus. It distinguishes initial treatment from management after an adequate initial intervention has failed.
Pediatric Chloral-Hydrate Meta-Analysis Separated Sedation Success From Onset and Duration
A pediatric meta-analysis reported higher sedation success with chloral hydrate than midazolam in the relevant pooled comparison, alongside longer onset and duration estimates. Those outcomes describe different tradeoffs.
Northern California Pandemic Study Found Lower Benzodiazepine Fills After Accounting for Prior Trends
A large health-system study found a small decrease in benzodiazepine prescription fills during the early pandemic. The result describes dispensing patterns within that system, rather than changes in individual consumption or impairment.
Geriatric Multimorbidity Study Combined Benzodiazepines With Opioids and Z-Hypnotics
A Norwegian hospital study linked greater illness burden with prolonged use of potentially addictive medications. Its combined exposure category prevents treating the association as a benzodiazepine-only effect.
Mephedrone and Benzodiazepine Cohort Linked HCV Status With Liver-Enzyme Findings
A hospital-record study associated combined mephedrone and benzodiazepine use with HCV infection, while identifying HCV as an important explanation for elevated liver enzymes. The association does not establish a direct drug-caused infection.
Saudi Hypnotic-Prescribing Audit Measured Documented Practice Against Selected U.S. Criteria
A single-hospital prescribing audit identified documentation gaps under historical audit criteria, with limits from incomplete retrospective records.
Sedative Death-Trend Study Used Broad ICD Categories That Could Not Identify One Benzodiazepine Interaction
Broad death-certificate sedative categories reveal population trends but cannot isolate a specific benzodiazepine interaction or individual cause.
Catatonia Case Improved During Combined Lorazepam and Aripiprazole Treatment
A combination-treatment catatonia case supports careful behavioral assessment, while leaving the separate drug contributions unresolved.
Benzodiazepine Synthesis Review Mapped Ring-Building Methods Rather Than Human Drug Effects
A synthetic-methods review informs chemical structure and preparation, while leaving human sedative effects and exposure interpretation unmeasured.