Milligrams per kilogram depends on which body-weight quantity forms the denominator.
Study findings
The matched gynecologic day-surgery analysis compared normal-weight and overweight or obese patients. Dose differences appeared when normalized to total or ideal body weight, but not clearly when normalized to lean or corrected body weight. The study did not perform a detailed pharmacokinetic analysis.
What limits the conclusion
Retrospective dose titration and matching cannot establish the optimal formula for every person. A normalization result does not measure clearance or distribution volume directly. High-risk medical conditions were not fully represented.
Implications for case review
Specify actual total milligrams and the weight convention before comparing records. Different denominators can create different numerical impressions without changing the administered amount. The paper cannot establish overdose, tolerance or a personal dose requirement from body-mass index alone.
Source and related reading
Source: PMC12379970, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
Related: Cat Midazolam–Pethidine Study Changed Dose as Well as Administration Route.
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