A tissue-to-plasma ratio and an absolute tissue concentration are different measurements.
What the paper found
Twelve rats received medetomidine, midazolam and fentanyl with or without vatinoxan. At fifteen minutes, cortex-to-plasma ratios were higher for all three drugs with vatinoxan. Absolute cortical increases were reported for medetomidine and fentanyl.
Limits of the evidence
One sampling time cannot define the full distribution course. A higher ratio may involve changes in numerator, denominator or both. The veterinary combination and species restrict transfer to human pharmacology or postmortem interpretation.
Implications for case review
Do not turn a ratio finding into an unreported absolute midazolam increase. Preserve matrix, time and every component of the regimen. The paper cannot supply a human brain concentration from a blood sample or establish that a particular behavioral effect resulted from one ingredient alone.
Source and related reading
Source: PMC12415804, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
Related: Mucociliary Clearance Was Preserved in One Midazolam-Containing Mouse Regimen.
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