All Articles
Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
Glutaric-Aciduria Anesthesia Case Combined Remimazolam With Metabolic Support
A favorable outcome after bundled care cannot identify which component made it possible. A four-year-old with glutaric aciduria type I underwent surgery using remimazolam anesthesia.
Palliative Midazolam Survey Described Practice Variation Rather Than Optimal Dosing
Reported practice is informative without being proof that the most common practice is best. An online survey asked palliative physicians in Norway, Denmark and the United Kingdom about midazolam indications, dosing and administration.
MAPK–ERK Manipulation Supported Remimazolam Liver-Injury Findings in Cells and Rats
A preclinical protective signal does not establish improved transplant outcomes in people. Researchers used hypoxia–reoxygenation cell models and rat liver ischemia–reperfusion experiments.
Zero Minutes to Awakening After Colonoscopy Did Not Mean Zero Drug Effect
A reported recovery interval needs its starting point and definition. A propensity-matched Japanese comparison reported much shorter post-colonoscopy awakening and discharge intervals with remimazolam than midazolam.
Intranasal Ketamine–Midazolam Sedation Was Less Consistent in Chickens Than Intramuscular Delivery
A shorter recovery interval may reflect less consistent sedation rather than a better overall regimen. A crossover veterinary experiment compared ketamine–midazolam by intranasal and intramuscular routes in twelve chickens.
Adolescent Awake Craniotomy Used Planned Remimazolam Discontinuation Before Testing
The timing of an awake assessment is part of the anesthetic strategy. A three-patient adolescent series added remimazolam to dexmedetomidine and remifentanil during selected craniotomy phases.
Cape Fur-Seal Disentanglement Used a Three-Drug Midazolam Mixture in a Distinct Environment
Veterinary field feasibility does not establish human anesthetic equivalence. A field report described medetomidine–midazolam–butorphanol sedation to permit removal of entangling material from Cape fur seals, with antagonist-supported recovery.
Korean Pediatric Endoscopy Sedation Patterns Reflected Centers as Well as Drugs
A multicenter practice comparison may incorporate staffing and monitoring differences. A study of 734 pediatric upper-endoscopy patients across institutions described several sedative combinations, including midazolam with other agents.
Lormetazepam Withdrawal Case Had Motor Seizures Without a Clear Ictal Scalp EEG
A negative scalp recording does not automatically settle the cause of stereotyped motor events. A case report described recurrent motor episodes after abrupt interruption of chronic lormetazepam misuse, with concurrent amitriptyline exposure.
Guggulsterone–Midazolam Interaction Findings Came From Experimental Systems
A traditional preparation’s interaction potential is not an established clinical magnitude. Researchers examined a polyherbal formulation and guggulsterone isomers using CYP3A-related laboratory testing and animal midazolam pharmacokinetics.
Dementia Dental Sedation Included Airway Events Despite Reduced Doses
Lower-than-usual dosing does not independently establish absence of respiratory risk. A retrospective series described sixty-two dental sedation episodes in nineteen patients with severe dementia.
Midazolam Phenotyping Required Attention to Hydroxymidazolam Deconjugation
A metabolite ratio changes meaning when the assay measures a different metabolite fraction. A healthy-volunteer cocktail study examined enzyme inhibition and induction.
Pexidartinib’s Midazolam Interaction Differed After Single and Repeated Exposure
An interaction cannot always be summarized by one time-independent percentage. Clinical probe studies evaluated pexidartinib with substrates of several enzymes and transporters.
Pandemic Fentanyl Positivity Rose Among Benzodiazepine-Positive Tests as Testing Volume Fell
Changes among tested specimens are not necessarily changes in the whole population. A national laboratory analysis reported a marked fall in test volume during early pandemic months.
Avitinib–Midazolam Laboratory Signals Were Not a Human Interaction Trial
Human liver material in an assay does not make every result a clinical observation. An avitinib study used rat and human liver microsomes and in-vivo rat probe experiments.
Benzodiazepine Driving Concentrations Were Estimated Rather Than Measured in an Exploratory Study
A modeled concentration category is not an actual laboratory result. An exploratory study compared long-term benzodiazepine-receptor-agonist users with controls on neurocognitive and on-road tasks.
Clobazam’s Effect in a Dravet Mouse Screen Depended on the Seizure Endpoint
Protection against a provoked seizure is not identical to prevention of all spontaneous seizures. A Dravet-model screening study used genetically altered mice and hyperthermia-induced seizures.
Supplemental Oxygen Prevented Hypoxia Without Correcting Acidosis in Sedated Rats
A reassuring oxygen measurement does not necessarily establish adequate carbon-dioxide elimination. Twelve postoperative rats received either oxygen or air after a fentanyl–fluanisone–midazolam anesthetic.
Fluoroethyltemazepam Radiotracer Production Did Not Validate a Specific Inflammation Test
Successful synthesis is an early development result rather than a clinical diagnostic validation. Researchers automated production of a fluorinated temazepam-derived PET ligand intended for TSPO investigation.
Respiratory-Stimulant Proposals for Mixed Overdose Are Not Established Benzodiazepine Antidotes
Stimulating respiration and reversing a specific drug mechanism are different pharmacological goals. A historical review discussed renewed interest in respiratory stimulants during the rise of mixed opioid and nonopioid exposures.
A Diazepam Comparator in a Canine Thunderstorm Study Did Not Establish Herbal Equivalence
A positive-control group does not make another treatment clinically interchangeable. A blinded beagle experiment compared a botanical tablet, placebo and diazepam during recorded thunderstorm noise.
Lake-Familiarized Perch Did Not Reproduce Every Laboratory Oxazepam Effect
Experimental environment can materially change the interpretation of drug-related behavior. An ecological study tested oxazepam exposure in perch familiarized to natural lake conditions.
A Bromazepam Stability Assay Separated Parent Drug From a Degradation Impurity
Measuring the intact medicine and measuring a degradation product are separate analytical tasks. A laboratory study developed a stability-indicating liquid-chromatographic assay for bromazepam and an identified impurity.
Canine Intranasal Benzodiazepine Absorption Varied With Formulation
The same drug and route can yield different exposure when the formulation changes. A veterinary review described intranasal midazolam and diazepam rescue options and summarized pharmacokinetic studies using solutions, gels and delivery devices.
Italian Lockdown Hair Findings Describe Multi-Month Benzodiazepine Exposure
A hair result reflects a different exposure window from a contemporaneous blood sample. Thirty people with substance-use disorders were monitored before, during and after Italy’s first lockdown using repeated hair analysis.
Mucociliary Clearance Was Preserved in One Midazolam-Containing Mouse Regimen
A favorable airway-clearance endpoint is not a complete measure of respiratory safety. A mouse imaging experiment compared anesthetics and measured movement of deposited tracer through respiratory clearance.
Brachytherapy Insertion Time Was Different From Total Sedation-Procedure Time
A procedural duration must be defined before it is used to evaluate sedative exposure. An outpatient brachytherapy series reported forty-seven insertions with midazolam–fentanyl sedation.
An Alprazolam Beverage Sensor Was Not Validated as a Blood-Impairment Test
Validation in one sample matrix cannot automatically be transferred to another. A laboratory method used electrochemically pretreated glassy carbon and stripping voltammetry to quantify alprazolam.
Five-Year Mortality Association Cannot Serve as an Acute Benzodiazepine Lethality Estimate
Long-term cohort mortality and the cause of one acute death are different questions. A South Korean population study matched benzodiazepine users and nonusers and used time-dependent regression.
A Febrile-Convulsion Paper’s Diazepam Comparison Contained a Directional Reporting Error
When prose and numerical results disagree, the discrepancy should be disclosed rather than silently resolved. A pediatric paper compared valproate with diazepam.