High completion rates can coexist with respiratory events that require immediate intervention.
What the publication shows
The retrospective series included 250 relatively healthy children receiving oral midazolam premedication followed by propofol deep sedation. Procedure success was 99.6%. Five laryngospasm episodes and seventeen episodes of mild hypoxia were reported; airway support was used to manage them.
Limits of the evidence
The study did not randomize premedication or compare the regimen with a benzodiazepine-free alternative. Recorded complications reflect the entire sedation process, and the sample does not represent all pediatric risk groups. A short average recovery time cannot exclude rare or delayed problems.
Application to expert review
For expert review, evaluate airway events, their duration and rescue measures alongside completion rates. Successful rescue should not erase the underlying event. Conversely, an event during a multidrug regimen cannot automatically be attributed to midazolam alone.
Source and related reading
Source: Publication PMC9242812. The case-review applications above are interpretive analysis.
Related reading: Dementia Dental Sedation Included Airway Events Despite Reduced Doses.
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